Endocrine Abstracts

Introduction: ALS is a neurodegenerative disease with a high prevalence of malnutrition. Nutritional diagnosis is important because of its prognostic implication.Objective: To determine the clinical and morphofunctional characteristics in a series of patients with ALS.Materials and methods: Cross-sectional descriptive study of patients seen at the multidisciplinary ALS clinic of the Hospital Puerta del Mar (Cádiz).<p class...

Introduction: Obesity is a known risk factor for hypovitaminosis D and although several studies point out that higher adherence to the Mediterranean Diet (Diet-Med) is associated with higher dietary vitamin D intake, there are very limited data on the influence of Diet-Med on serum 25-Hydroxy Vitamin D (25OHD) levels. Our aim was to evaluate the relationship between adherence to Diet-Med and vitamin D status in obese patients.Material and Methods: Retros...

Introduction: For the past three years, patients with type 1 diabetes have been treated with basal-bolus therapy at the Axarquia Hospital by doctors from the Clinical Management Unit of Endocrinology and Nutrition at the Malaga Regional University Hospital. Treating patients in their own health area avoids travel and could have an impact on better follow-up, metabolic control, and the incidence of complications. The aim of this study is to describe the socio-demographic and cl...

Introduction and Objectives: Continuous glucose monitoring (CGM) has demonstrated benefits in the prevention of hypoglycemia in patients with type 1 diabetes mellitus (DM1) vs flash monitoring (CGM). Our aim was to analyze the clinical characteristics, indication and glucometric changes in patients using MFG after CGM implantation.Material and methods: Retrospective observational study of 13 patients under follow-up for DM1 in Endocrinology consultations...

Introduction: Hypophysitis, an infrequent inflammatory condition of the pituitary gland, is typically managed with glucocorticoids, reserving surgery for significant mass effects and considering immunosuppressants or radiotherapy for refractory cases. Recent reports indicate positive outcomes with immunosuppressants. Here, we present a case of recurrent xanthogranulomatous hypophysitis in a 16-year-old female successfully treated with Rituximab.Case Repo...

Objective: Endogenous cushing syndrome (ECS) is a complex and rare disease. After treatment, 50% of cases have recurrence. The objective is to evaluate the prevalence of recurrences in patients diagnosed of ECS and its predictive factors.Materials and Methods: Analytical retrospective observational study with 19 ECS diagnoses cases followed-up from January 1999 to December 2023. Demographic (sex, age), clinical (cause, face plethora, fragile capillary, r...

Introduction: MUTYH (MutY homolog Escherichia coli, homolog of MYH, hMYH) is a repair enzyme with a crucial role in the correction of DNA errors, being considered a protective factor of the cell. MUTYH mutations have been linked to MUTYH-associated polyposis syndrome (MAP), an autosomal recessive disorder characterized by multiple colorectal adenomas. Patients with MAP show a much higher lifetime risk of gastrointestinal cancers as an additional role of MUTYH, it appears to co...

Introduction: Advanced differentiated thyroid carcinoma (aDTC) – herein defined as locally unresectable or metastatic disease – is one of the most common late-stage endocrine neoplasias. However, available data about its natural history is limited. ERUDIT is a multicenter, observational, retrospective study of patients diagnosed with aDTC in Spain and Portugal. The study describes its natural history from the initial diagnosis until the advanced stages of disease, ...

Type 2 diabetes is among the most prevalent chronic diseases worldwide. Further research is needed to identify new mechanisms that may help preserve the function of insulin-secreting pancreatic β-cells. The cannabinoid receptors type 1 (CB1) and their endogenous ligands, endocannabinoids, exert a key role in regulating of glucose homeostasis, β-cells function, and insulin secretion. Intriguingly, CB1 is not only located at the plasma membrane (pmCB1), but also at the...

Introduction: Because of the increase of brain image explorations, the prevalence of pituitary tumours has increased a lot. Although most of them have an indolent behaviour, some behave aggressively, demanding a lot of resources for their management. Therefore, it is very important to identify them as soon as possible. The recent WHO 2017 classification of pituitary tumours gives insights into improving their identification using the immunostaining (IS) of transcription factor...